23 Abstract: The effects of acute GrayanotoxinI (GTX-I) administration on hepatic and renal functions in rats were investigated. GTX-I was administrated to the animals of groups 1, 2 and 3 at a single i.p. dose of 1 mg/kg, 0.5 mg/kg and 0.25 mg/kg respectively, and group 4 (control) received i.p. saline (0.9 %) solution only. One hour following the administration of GTX-I or saline, urine analy...

Activ~ties of lactic dehydrogenase (LDH), glutamate oxaloacetate transanunase (GOT) and glutamate pyruvate transaminase (GPT) were measured in blood plasma and some tissues of grey mullet Mugd auratus Risso. After determination of optimal assay conditions, cardiac sampling for LDH estimation was recommended. Tissue distribution of enzymers and their origln in plasma were described, in particula...

Hemorrhagic shock (HS) following acute alcohol intoxication can increase proinflammatory cytokine production and induce marked immunosuppression. We investigated the effects of ethanol on physiopathology and cytokine levels following HS in acutely alcohol-intoxicated rats. Rats received an intravenous injection of 5 g/kg ethanol over 3 h followed by HS induced by withdrawal of 40% of total bloo...

The influence of single oral dose of anti-inflammatory, antipyretic and analgesic agents on urinary enzymes was investigated in rats as a indicator of nephrotoxic effect. Urinary LDH activity was significantly elevated by aspirin, ketophenylbutazone, aminopyrine, phenacetin and acetaminophen. These drugs increased also H/M ratio of LDH isoenzymes. Although other test drugs have no effect on LDH...

A correlation was made between the urinary excretion of GOT, GPT, LDH, HBD, and acid and alkaline phosphatase and their serum activity in 18 suspected cases of myocardial infarction. The diagnoses were made by a cardiologist without knowledge of the enzyme assays. The study included 2 cases of nontransmural infarction; 5 cases that had not sustained an infarction served as controls. Elevations ...

A new method to assay the enzyme, leucine aminopeptidase (LAP; L-leucyl-peptide hydrolase.-3.4.1.1), is described. The technic is an extension of the conventional glutamic-pyruvic transaminase (GPT) reaction. Serum LAP is allowed to react with the substrate L-leucyl-L-alanine to quantitatively generate alanine. This alanine, in the presence of excess -ketoglutaric acid and GPT, rapidly forms py...

AIM To investigate various biochemical components of seminal plasma in Marwari stallions and Poitou Jacks and to find out their correlation with that of the seminal characteristics. MATERIALS AND METHODS In this study, semen was collected from six Marwari stallions and six Poitou jacks aged from 4 to 6 years and with known fertility status. The semen collection from the stallions were collect...

To consider potentially new hypoglycemic and antihyperlipidemic sources, aqueous extracts from four Korean medicinal plants, Chrysanthemum coronarium, Dioscorea batatas, Morus alba, Citrus unshiu, were investigated in alloxan-induced diabetic rats. To induce diabetes, 36 rats were administered alloxan orally (120 mg/kg body weight) for 2 weeks and among those 6 rats were used as a diabetic cont...